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FLASH GENE
Symbol IFNAR1 contributors: mct - updated : 08-03-2015
HGNC name interferon (alpha, beta and omega) receptor 1
HGNC id 5432
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Hearing/Equilibriumear   highly
Reproductivefemale systemovary   
Urinarybladder   highly
 kidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three fibronectin type III domains
HOMOLOGY
Homologene
FAMILY cytokine receptor family II
CATEGORY signaling cytokine , receptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,endosome
intracellular,nucleus
text
  • can translocate to the nucleus following IFN beta stimulation
  • shortly after IFN stimulation, robustly ubiquitinated IFNAR1 were found in the endosomal compartment
  • basic FUNCTION
  • interferon alpha/beta (type I), receptor, alpha subunit conferring high affinity to the receptor
  • functioning as an antiviral factor
  • its ubiquitination promotes its interaction with the AP2 adaptin complex required for the robust internalization of IFNAR1, implicating cooperation between site-specific ubiquitination and the linear endocytic motif in regulating this process
  • trafficking of the IFN receptor (IFNAR1 and IFNAR2) through endosomes may potentially regulate signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with TYK2 and positively influencing ligand binding to the receptor complex (catalytic activation of TYK2 is not essential for IFNAR1 internalization, but is required for ligand-induced IFNAR1 serine phosphorylation, ubiquitination and efficient lysosomal proteolysis)
  • TRAF2 rapidly binds to the IFNAR1 subunit of the IFN receptor upon IFN binding (role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response)
  • intercating with IFNA1 (palmitoylation of IFNAR1 is required for the activation of STAT1 and STAT2 by IFNA1)
  • expression and kinase activity of PRKD2 are required for the ligand-inducible stimulation of IFNAR1 ubiquitination and endocytosis and for accelerated proteolytic turnover of IFNAR1
  • PTPN1 is a specific regulator of IFNAR1 endocytosis stimulated by IFN1, but not by ligand-independent inducers of IFNAR1 ubiquitination
  • . PTPN1 is a specific regulator of IFNAR1 endocytosis stimulated by IFN1, but not by ligand-independent inducers of IFNAR1 ubiquitination
  • IFNB1 can uniquely and specifically ligate to IFNAR1 in an IFNAR2-independent manner
  • TYK2-IFNAR1 interface reveals an unexpected receptor-binding mode that mimics a SH2 domain-phosphopeptide interaction, with a glutamate replacing the canonical phosphotyrosine residue
  • ZG16B conferred resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNAR1-mediated signaling
  • cell & other
    REGULATION
    Other inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to chronic HBV infection
  • to multiple sclerosis
  • Variant & Polymorphism SNP , other
  • two linked single nucleotide polymorphisms (SNPs) at -408 and -3 of IFNAR1 promoter are associated with susceptibility to chronic HBV infection
  • IFNAR1 mRNA level is lower in multiple sclerosis patients than in healthy controls
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS