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FLASH GENE
Symbol THEMIS contributors: mct/npt - updated : 05-01-2010
HGNC name thymocyte selection associated
HGNC id 21569
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymuscortex  specific
cell lineage high expression in thymocytes between the pre-T cell antigen receptor (pre-TCR) and positive-selection checkpoints and low expression in mature T cells (Fu 2009)
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal Src homology 3 domain
    • HOMOLOGY
    Homologene
    FAMILY
  • themis family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text cytosolic protein (Patrick 2009)
    basic FUNCTION
  • phosphorylated quickly after TCR stimulation and needed for optimal TCR-driven calcium mobilization and activation of the kinase Erk, and involved in TCR signaling (Fu 2009)
  • critical component of the T cell developmental program and may functions to sustain and/or integrate signals required for proper lineage commitment and maturation (Lesourne 2009)
  • T cell-specific protein important for late thymocyte development (Lesourne 2009)
  • playing a a unique function in sustaining positive selection (Johnson 2009)
  • may acts as a thymocyte-specific adaptor for GRB2 or regulates Ras signaling in double positive thymocytes (Patrick 2009)
  • critical in positive selection but not in other TCR-related signal transduction events (Patrick 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • constitutively associates with GRB2 via its N-terminal Src homology 3 domain (Patrick 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS