Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol N4BP2L2 contributors: mct - updated : 27-11-2009
HGNC name NEDD4 binding protein 2-like 2
HGNC id 26916
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
text is also located in the nucleus
basic FUNCTION
  • mediates neutrophil elastase and GFI1 transcriptional repressor cooperation
  • may have a role in promoting the maturation of the C-terminus of neutrophil elastase
  • required for neutrophil elastase transcriptional activity prior to the removal of the C-terminus and only once the propeptide is removed does neutrophil elastase become transcriptionally active
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ELA2 and GFI1 (mediating transcriptional repressor cooperation between GFI1 and Neutrophil Elastase)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS