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FLASH GENE
Symbol MREG contributors: mct - updated : 01-02-2017
HGNC name melanoregulin
HGNC id 25478
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Digestiveliver   highly Homo sapiens
Lymphoid/Immunethymus   highly Homo sapiens
Skin/Tegumentskin   highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentmelanocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • melanoregulin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text localizes to small intracellular vesicles and associates with the endosomal phosphoinositide, phosphatidylinositol 3,5-biphosphate
    basic FUNCTION
  • involved in pigmentation of the mammalian hair
  • required in lysosome-dependent phagosome degradation and having a role in intracellular trafficking
  • function at a stage of the lysosome maturation process downstream of early endosomes likely at the late endosomes/lysosome stage
  • regulates microtubule-dependent retrograde melanosome transport through the dynein-dynactin motor complex
  • is a negative regulator of melanosome transfer
  • melanoregulin targeting to melanosomes and lysosomes requires N-terminal cysteines
  • functions as a negative regulator of a shedding mechanism that drives the intercellular transfer of melanosomes from the melanocyte to the keratinocyte
  • intracellular cargo-sorting protein required for the degradation of Photoreceptor outer segment (POS) disks
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PRPH2 forms a complex with melanoregulin (MREG)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacted with the C-terminal domain of RILP and formed a complex with RILP and DCTN1 (dynein-dynactin motor complex recognizes MREG on mature melanosomes through interaction with RILP and is involved in the centripetal movement of melanosomes)
  • is likely required to maintain CTSD homeostasis in the RPE and likely plays a protective role in retinal health
  • cell & other
    REGULATION
    Other multiple palmitoylation serves to stably anchor melanoregulin in the melanosome membrane
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to age-related retinal changes
    Variant & Polymorphism other mutations in MREG may be a risk factor in age-related retinal changes
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS