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FLASH GENE
Symbol SLC46A1 contributors: mct/npt/pgu - updated : 20-07-2009
HGNC name solute carrier family 46 (folate transporter), member 1
HGNC id 30521
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 parathyroid   highly
Lymphoid/Immunespleen   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • major facilitator superfamily
  • SLC46A family
  • CATEGORY transport carrier channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having a critical role to intestinal folate absorption and transport into the central nervous system
  • might play also a role in another transport pathway, folate receptor (FR)-mediated endocytosis
  • mediates intestinal folate uptake at acidic pH
  • NRF1-responsive gene
  • functions as a folate-proton co-transporter in the acidic microclimate of the upper small intestine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CFM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS