basic FUNCTION
| PLEKHA7/NEZHA complex regulates the zonula adherens integrity by recruiting KIFC3 to this junctional site |
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specifically important for the cadherin-catenin accumulation at the zonula adherens |
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cytoplasmic component of the epithelial adherens junction belt, with a subcellular localization and tissue distribution that is distinct from that of TJP1 and most adherens junctions proteins |
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TJP1 and PLEKHA7 are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively |
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PLEKHA7, together with CNGL1, is part of a protein complex that links CDH1 to the microtubule cytoskeleton at AJs |
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plays a cooperative role with nectin and MLLT4 in the proper formation of AJ (Adherens Junction) in epithelial cells |
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likely PLEKHA7 regulates at least partly the association of the nectin-afadin and cadherin-catenin systems |
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the role for PLEKHA7 in the proper formation of AJ may contribute to the formation of AJ specifically in epithelial cells |