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FLASH GENE
Symbol GYPC contributors: mct - updated : 28-11-2018
HGNC name glycophorin C (Gerbich blood group)
HGNC id 4704
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeanterior segment   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerthrocyte
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
CATEGORY antigen
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytoskeleton
text type3 membrane protein
basic FUNCTION
  • plasmodium falciparum receptor, playing an important role in regulating the stability of red cells
  • encodes two erythrocyte surface sialoglycoproteins in humans, glycophorin C and glycophorin D (GYPC and GYPD), via initiation of translation at two start codons on a single transcript
  • crucial role of GYPC for P. berghei infection
  • GYPA, GYPB receptor are of greater importance than the GYPC receptor, supporting a hierarchy of erythrocyte receptor usage in P. falciparum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GRBG
    related resource Blood Group Antigen Mutation Database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS