Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GYPB contributors: mct - updated : 28-11-2018
HGNC name glycophorin B (MNS blood group)
HGNC id 4703
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerthrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • carbohydrate rich sialoglycoprotein
  • conjugated GlycoP , Other
    HOMOLOGY
    interspecies homolog to C.elegans F26E4.6
    intraspecies paralog to GYPA
    Homologene
    FAMILY
  • glycophorin A family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • GYPA, GYPB receptor are of greater importance than the GYPC receptor, supporting a hierarchy of erythrocyte receptor usage in P. falciparum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component major protein constituent of erythrocyte membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DUP4 is a complex structural genomic variant that carries extra copies of GYPA-GYPB fusion gene and has a dramatic effect on malaria risk by reducing the risk of severe malaria by up to 40p100
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MNS
    related resource Blood Group Antigen Mutation Database
    Susceptibility to variable risk of severe malaria
    Variant & Polymorphism other
  • DUP4 variant confers a clinically important protective effect, with carriers &
  • 8764;40p100 less likely to develop cerebral malaria
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS