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FLASH GENE
Symbol LRRC26 contributors: mct - updated : 25-06-2014
HGNC name leucine rich repeat containing 26
HGNC id 31409
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon lowly Homo sapiens
 intestinesmall intestine  lowly Homo sapiens
 salivary gland   highly Homo sapiens
 stomach   lowly Homo sapiens
Reproductivemale systemprostate  highly Homo sapiens
 male systemtestis  lowly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretory    Homo sapiensAdult
cell lineage restricted expression in normal tissues
cell lines in many cancers and cancer cell lines
fluid/secretion
at STAGE
physiological period fetal
Text low in fetal brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a classical N-terminal cleavable signal peptide for extracellular localization of its large N-terminal LRR domain (five 24-AA LRR motifs with a consensus sequence LXXLXLXXN)
  • a single transmembrane domain
  • a short intracellular C terminus
  • HOMOLOGY
    intraspecies paralog to LRRC55, LRRC38, LRRC52
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton
    text type I single-span membrane protein
    basic FUNCTION
  • modulates the gating of KCNMA1 by enhancing the allosteric coupling between voltage-sensor activation and the channel closed–open transition
  • role in the suppression of tumor growth and metastasis may be through its alteration of the tumor microenvironment
  • LRRC52 and LRRC26 define a new family of auxiliary subunits capable of critically modifying the gating behavior of Slo family channels
  • LRRC52, LRRC55, and LRRC38 potentially function as LRRC26-type auxiliary subunits of BK channels
  • LRRC26 and its paralogs are structurally and functionally distinct from the beta-subunits and are a gamma family of the BK channel auxiliary proteins, which potentially regulate the channel gating properties over a spectrum of different tissues or cell types
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • belongs to an extracellular leucine-rich-repeat–only (Elron) cluster, which includes five other LRRC proteins: LRRC38, LRRC52, LRRC55, LRTM1 and LRTM2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • auxiliary protein of BK channels that can associate with KCNMA1
  • both LRRC26 and LRRC52 are able to modify KCNU1 function
  • associates with KCNMA1 subunits, and elevates channel voltage- and apparent Ca2+-sensitivity in arterial myocytes to induce vasodilation (PMID;
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate, breast, colon and pancreas cancer tissues or cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS