Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol COL8A2 contributors: shn/npt - updated : 08-12-2009
HGNC name collagen, type VIII, alpha 2
HGNC id 2216
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Skin/Tegumentskin    
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelialbarrier liningcorneal endothelium  
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a triple-helical and a carboxyl non-triple-helical domain
  • one C1q C terminal domain
  • one NC1 and one NC2 domain
  • conjugated GlycoP
    mono polymer homomer , heteromer , trimer
    HOMOLOGY
    interspecies ortholog to Col8a2, Mus musculus
    ortholog to Col8a2, Rattus norvegicus
    ortholog to COL8A2, Pan troglodytes
    Homologene
    FAMILY
  • short chain collagen family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text vascular subendothelial matrices
    basic FUNCTION
  • playing a role in the structure of cornea
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • a major constituent of Descemet membrane (posterior lining membrane of cornea)
  • a major component of the subendothelial matrix
  • has the potential to improve both initial cell attachment and retention of endothelial cells on vascular grafts in vivo (Turner 2006)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • collagen, type VIII, alpha 1 (COL8A1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FECD1 , PPCD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS