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FLASH GENE
Symbol CCDC88B contributors: mct - updated : 05-02-2009
HGNC name coiled-coil domain containing 88B
HGNC id 26757
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus containing a putative microtubule-binding domain that can bind microtubules in the Hook protein
  • the central region of each protein is comprised of an extensive coiled-coil domain
  • several conserved domains, including a unique C-terminal HkRP domain (Simpson 2005)
  • HOMOLOGY
    Homologene
    FAMILY
  • Hook-related protein (HkRP) family, CCDC88 family
  • Girdin family protein
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be functioning in linking organelles to microtubules*
  • having a protective role in endoplasmic reticulum stress responses in endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CCDC88B/GRP78 interaction controls the IRE1-JNK signaling pathway to protect endothelial cells against ER stress-induced apoptosis in pathological contexts such as atherosclerosis and vascular endothelial dysfunction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in endothelial cells, interacts with GRP78, a master regulator of the unfolded protein response
  • stabilizes the interaction between GRP78 and the ER stress sensor inositol-requiring protein 1 (IRE1) at the ER, leading to the attenuation of IRE1-induced c-Jun N-terminal kinase (JNK) activation
  • cell & other
    REGULATION
    induced by upon ER stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS