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FLASH GENE
Symbol GXYLT2 contributors: SGE/npt - updated : 15-04-2010
HGNC name glucoside xylosyltransferase 2
HGNC id 33383
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short N-terminal cytoplasmic domain
  • a transmembrane domain
  • a stem region with an arginine- and proline-rich insertion (as compared to GXYLT1)
  • a large glycosyltransferase domain containing the conserved DxD motif
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Glt8d4 (89.8pc)
    homolog to rattus Glt8d4 (88.9pc)
    Homologene
    FAMILY
  • glycosyltransferase 8 family (GT8 family)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type II membrane protein
    basic FUNCTION
  • elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose
  • GXYLT1 and GXYLT2 (glucoside-xylosyltransferase 1/2), are able to transfer the first alpha1,3-linked xylose to O-glucosylated mammalian Notch EGF repeats
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS