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FLASH GENE
Symbol C22orf39 contributors: mct - updated : 17-10-2023
HGNC name chromosome 22 open reading frame 39
HGNC id 27012
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
 brainlimbic system    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • extrasynaptic C22orf39 is downregulated in response to neuronal activity
  • stabilizes the interaction of RTN4 with receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C22orf39 interaction with RTN4 augments its influence over postsynaptic AMPA receptor clustering, thus gating plasticity at adult synapses
  • C22orf39 interacts with proteins important for plasticity, cognitive disease, and aging
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in early adulthood in the mossy fiber circuit of the hippocampus
    Susceptibility to schizophrenia
    Variant & Polymorphism insertion/deletion its microdeletion conveys a high risk for schizophrenia
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS