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FLASH GENE
Symbol FDX1L contributors: mct - updated : 20-11-2017
HGNC name ferredoxin 1-like
HGNC id 30546
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   moderately
Reproductivemale systemprostate  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text predominantly in umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 2Fe-2S ferredoxin-type domain
    • HOMOLOGY
    interspecies ortholog to functional orthologue of yeast Yah1
    homolog to rattus Fdx1l (85.1 pc)
    homolog to murine Fdx1l (83.9 pc)
    Homologene
    FAMILY
  • adrenodoxin/putidaredoxin family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text
  • present in the matrix of human mitochondria
    • basic FUNCTION
  • involved in electron transport chain
  • essential for Fe/S protein biogenesis in human cells and can functionally replace FDX1 (Sheftel 2010)
  • unlike FDX1, is unable to reduce mitochondrial cytochrome P450 (Sheftel 2010)
  • involved in heme A formation and Fe/S protein biogenesis, and is also essential for the maturation of cytosolic Fe/S proteins, underscoring the importance of mitochondria in all Fe/S protein production in the eukaryotic cell (Sheftel 2010)
  • is the second component of the Fe-S cluster biogenesis machinery, the first being ISCU that is associated with isolated mitochondrial myopathy
  • FDX1L, FDX1, play an important role as an electron donor in iron-sulfur (Fe-S) cluster biosynthesis
  • FDX1L, FDX1 can function in Fe-S cluster assembly
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
  • essential component of the Fe/S protein biogenesis pathway (Sheftel 2010)
    • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • binding to a 2Fe-2S cluster
    • protein
  • interference with any of the three related genes, FDX1, FDX1L or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS