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FLASH GENE
Symbol CCDC62 contributors: SGE/mct - updated : 29-06-2022
HGNC name coiled-coil domain containing 62
HGNC id 30723
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cell lineage
cell lines PCa cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled-coil domain
  • HOMOLOGY
    interspecies homolog to murine Ccdc62 (77.7pc)
    homolog to rattus Ccdc62 (78.4pc)
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • functioning as a coactivator that can modulate ER-beta transactivation and receptor function in prostate cancer cells (Chen 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ER-alpha (Chen 2008)
  • cell & other
    REGULATION
    Other ER-alpha coactivator in prostate stromal cells (Chen 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF67
    Susceptibility to Parkinson disease (PD)
    Variant & Polymorphism other
  • significant association between rs12817488 and PD risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS