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FLASH GENE
Symbol ETAA1 contributors: mct - updated : 09-05-2023
HGNC name Ewing tumor-associated antigen 1
HGNC id 24648
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Lymphoid/Immunelymph node   moderately
Reproductivefemale systembreastmammary gland predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled coil domain
  • two RPA-interaction motifs that localize ETAA1 to stalled replication forks
  • HOMOLOGY
    interspecies homolog to rattus Etaa1 (56.5 pc)
    homolog to murine Etaa1 (55.4 pc)
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • functioning as a tumour-specific cell surface antigen (Borowski 2006)
  • ETAA1 is a novel RPA1-interacting protein that promotes restart of stalled replication forks
  • ETAA1 functions in parallel to the TOPBP1/RAD9/HUS1/RAD1 pathway to regulate ATR and maintain genome stability
  • identification of ETAA1 as a DNA replication stress response protein
  • ETAA1 is a likely new ATR activator involved in replication checkpoint control
  • likely an important role of ETAA1 in protecting against genome instability arising from incompletely duplicated DNA via regulatory control of its ATR-stimulating potential
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ETAA1 binds ATR/ATRIP directly using a motif with sequence similarity to the TOPBP1 ATR-activation domain
  • specifically interacts with RPA (Replication protein A) via two conserved RPA-binding domains and is therefore recruited to stalled replication forks
  • ETAA1 is an important activator of ATR in human cells, providing insights into how the ATR pathway reacts to replication stress
  • TOPBP1 and ETAA1 activate ATR using similar motifs and mechanisms
  • TOPBP1 and ETAA1 dimerization is important for optimal ATR signaling and genome stability
  • prominent RPA1-interacting partners are the tumor suppressor protein TP53, RAD51, ATRIP and ETAA1
  • cell & other
    REGULATION
    Other phosphorylated upon DNA damage, probably by ATM or ATR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS