protein
| ETAA1 binds ATR/ATRIP directly using a motif with sequence similarity to the TOPBP1 ATR-activation domain |
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specifically interacts with RPA (Replication protein A) via two conserved RPA-binding domains and is therefore recruited to stalled replication forks |
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ETAA1 is an important activator of ATR in human cells, providing insights into how the ATR pathway reacts to replication stress |
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TOPBP1 and ETAA1 activate ATR using similar motifs and mechanisms |
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TOPBP1 and ETAA1 dimerization is important for optimal ATR signaling and genome stability |
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prominent RPA1-interacting partners are the tumor suppressor protein TP53, RAD51, ATRIP and ETAA1 |