Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TTYH3 contributors: KTN/npt - updated : 05/11/2008
HGNC name tweety homolog 3 (Drosophila)
HGNC id 22222
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   moderately
 salivary gland   predominantly
Reproductivefemale systemovary  moderately
Skin/Tegumentskin   highly
Urinarykidney   moderately
Visualeye   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text highly in embryonic tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane domains
  • a glutamate and aspartate-rich Ca(2+) bowl-like sequence
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog TTYH3 (92 pc)
    homolog to rattus Ttyh3 (94.8 pc)
    homolog to murine Ttyh3 (94.6 pc)
    homolog to chicken TTYH3 (76.8 pc)
    Homologene
    FAMILY
  • tweety family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text multi-pass membrane protein
    basic FUNCTION
  • being a probable large-conductance Ca(2+)-activated chloride channel
  • may play a role in Ca(2+) signal transduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text Cl- transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Cl-
  • Ca2+
  • protein
    cell & other
    REGULATION
    Other N-glycosylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS