Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LRTOMT contributors: npt - updated : 27-10-2008
HGNC name leucine rich transmembrane and 0-methyltransferase domain containing
HGNC id 25033
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunespleen    
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumstereocilia
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • catechol-O-methyltransferase domain
  • a transmembrane domain
  • HOMOLOGY
    interspecies homolog to murine Comt2 (92.64p100)
    Homologene
    FAMILY
  • methyltransferase superfamily
  • catechol-O-methyltransferase family
  • CATEGORY enzyme , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • playing an essential role for auditory and vestibular function
  • leucine-rich protein and a methyltransferase, which has evolved from the fusion of two neighboring ancestral genes, which exist as separate genes (LRRC51 and TOMT) in rodents
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission , sensory transduction/hearing
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB63
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS