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FLASH GENE
Symbol SDE2 contributors: npt - updated : 02-12-2020
HGNC name SDE2 telomere maintenance homolog
HGNC id 26643
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Reproductivefemale systemuteruscervix  
Urinarybladder    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal ubiquitin-like (UBL) fold, which is cleaved at a diglycine motif via a PCNA-interacting peptide (PIP) box and deubiquitinating enzyme activity, and UBL domain plays an important role in regulating replication stress response
  • a DNA-binding SAP (SAF-A/B, Acinus and PIAS) domain (SAP domains are frequently found in proteins participating in the DNA repair process)
  • cleaved C-terminal SDE2 is required for antagonizing PCNA monoubiquitination triggered by ultraviolet (UV) damage
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • possible function in the DDR or in DNA repair
  • may be involved in a confined and specific DNA repair pathway, which is often the case with distinct DNA repair factors
  • is a new factor required for counteracting replication stress
  • PCNA-associated protein, playing a key role in maintaining active replication and counteracting replication stress by regulating the replication fork protection complex (FPC)
  • essential role for SDE2 in maintaining genomic integrity by stabilizing the FPC
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SDE2 is a new genome surveillance factor regulated by PCNA interaction
  • SDE2 facilitates spliceosomal association of CACTIN/Cay1, with a functional link between SDE2 and CACTIN further supported by genetic interactions and pre-mRNA splicing assays
  • conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks
  • SDE2 directly interacts with the FPC component TIMELESS (TIM) and enhances its stability, thereby aiding TIM localization to replication forks and the coordination of replisome progression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS