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FLASH GENE
Symbol ERCC6L2 contributors: mct - updated : 11-03-2014
HGNC name excision repair cross-complementation group 6-like 2
HGNC id 26922
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
Endocrineadrenal gland    
 parathyroid   highly
Lymphoid/Immunelymph node    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal DEAH ATP-helicase domain, and a distinct 13 amino acid N-terminal sequence that harbors a putative mitochondrial targeting sequence
  • a catalytic helicase C-terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
  • SNF2/RAD54 helicase family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • translocate to the mitochondria and the nucleus in response to DNA damage
  • basic FUNCTION
  • implicated in DNA repair and mitochondrial function
  • plays a role in the DNA-damage-response pathway
  • traffics to the mitochondria and nucleus in a ROS-dependent fashion in response to DNA damage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BMFND
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS