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FLASH GENE
Symbol CLRN2 contributors: mct - updated : 11-04-2023
HGNC name clarin 2
HGNC id 33939
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to rattus Clrn2 (93.5 pc)
homolog to murine Clrn2 (87.1 pc)
Homologene
FAMILY
  • clarin family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • integral to membrane
  • multi-pass membrane protein
  • basic FUNCTION
  • may play a role for clarin-1 in hair cell and photoreceptor cell synapses
  • while it is not required for initial formation of cochlear sensory hair cell stereocilia bundles, CLRN2 is critical for maintaining normal bundle integrity and functioning
  • key role for CLRN2 in mammalian hearing, providing insights into the interplay between mechano-electrical transduction and stereocilia maintenance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    sensory synapses
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB117
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS