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FLASH GENE
Symbol CENPN contributors: SGE - updated : 30/09/2008
HGNC name centromere protein N
HGNC id 30873
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   predominantly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuteruscervix moderately
 male systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies homolog to rattus Cenpn (71.9 pc)
homolog to murine Cenpn (73.3 pc)
homolog to chicken CENPN (61 pc)
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome,centromere
intracellular,nucleus,chromatin/chromosome,kinetochore
basic FUNCTION
  • playing a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation
  • recruiting the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres
  • CELLULAR PROCESS cell cycle, division, mitosis
    nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CENPA-NAC (nucleosome-associated) complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU
  • constitutive centromere-associated network (CCAN) component (Hori 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS
  • binding selectively CENPA-nucleosomes but not H3-nucleosomes and recruiting other proteins to centromeric chromatin that are required for centromere function and propagation (Carroll 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS