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FLASH GENE
Symbol NDUFS1 contributors: mct - updated : 16-10-2010
HGNC name NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
HGNC id 7707
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
 digestive
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure thirty different subunits
mono polymer polymer
HOMOLOGY
interspecies homolog to bovine NDUFS1
homolog to C.elegans y45-g12b.1
Homologene
FAMILY
  • complex 1, 75kDa subunit family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • NADH ubiquinone dehydrogenase (Q reductase)
  • NADH-Coq reductase (complex I),Fe-S subunit
  • contains 3 iron–sulfur clusters, N1b, N4 and N5 and plays an important role in the electron transfer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
  • largest subunit of complex I and is located in the iron–sulfur fragment of the enzyme
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDUFS1
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS