basic FUNCTION
| is an essential component of the mitochondrial Ca(2+) uniporter |
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is essential for glucose-induced ATP increases in pancreatic beta-cells |
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crucial role of MICU1 and MCU in mitochondrial Ca(2+) uptake in pancreatic beta-cells and their involvement in the positive feedback required for sustained insulin secretion |
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encodes the pore-forming subunit of the uniporter channel |
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increases mitochondrial Ca(2+) levels following NMDA receptor activation, leading to increased mitochondrial membrane depolarization and excitotoxic cell death |
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MCU and the pathways regulating its expression as important determinants of excitotoxicity, which may represent therapeutic targets for excitotoxic disorders |
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plays an important role in mitochondrial matrix Ca(2+) influx |
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plays a critical role in breast cancer cell migration by regulating store-operated Ca2+ entry (SOCE |
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is a conserved Ca(2+) transporter at mitochondrial in eukaryotic cells |
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may be dispensable for homeostatic cardiac function but required to modulate Ca(2+)-dependent metabolism during acute stress |
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mitochondrial Ca(2+) uptake is primarily mediated by MCU |
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is a dedicated regulator of short-term mitochondrial Ca(2+) loading underlying a "fight-or-flight" response that acutely matches cardiac workload with ATP production |
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mitochondrial uniporter (MCU) is an ion channel that mediates Ca(2+) uptake into the matrix to regulate metabolism, cell death, and cytoplasmic Ca(2+) signaling |