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FLASH GENE
Symbol BORA contributors: mct - updated : 24-09-2014
HGNC name chromosome 13 open reading frame 34
HGNC id 24724
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • BORA family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • in interphase cells, is a nuclear protein, but upon entry into mitosis, BORA is excluded from the nucleus and translocates into the cytoplasm in a CDC2-dependent manner
  • basic FUNCTION
  • accumulates in the G2 phase and promotes AURKA-mediated activation of Polo-like kinase 1 (PLK1), leading to the activation of cyclin-dependent kinase 1 and mitotic entry
  • with AURKA control mitotic entry, which provides a mechanism for one of the most important yet ill-defined events in the cell cycle
  • regulates spindle stability and microtubule polymerization and promotes tension across sister kinetochores during mitosis (tight regulation of the BORA protein by its synthesis and degradation is critical for cell cycle progression)
  • synergistic action of BORA and the kinase Aurora A (AURKA) controls the G2-M transition
  • is an essential mitotic kinase regulating multiple aspects of the cell division process
  • its degradation compromises PLK1 activation and contributes to DNA damage-induced G2 arrest
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with PLK1 and controls the accessibility of its activation loop for phosphorylation and activation by AURKA
  • interacts with PLK1 and BTRC ubiquitin ligase (implicated in BORA degradation by proteasomes in mitosis)
  • interacting wth AURKA (activation of CDC2 initiates the release of BORA into the cytoplasm where it can bind and activate Aurora-A)
  • BORA/AURKA-dependent phosphorylation is a prerequisite for PLK1 to promote mitotic entry after a checkpoint-dependent arrest
  • PLK1 controls AURKA localization and function by regulating cellular levels of BORA
  • PIN1 acts as a negative regulator of the G2/M transition by interacting with the AURKA-BORA complex
  • BRCA1 downregulates the kinase activity of PLK1 by modulating the dynamic interactions of AURKA, BORA, and PLK1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    induces mislocalization of AURKA and monopolar spindle formation, reminiscent of the phenotype seen in PLK1-depleted cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS