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FLASH GENE
Symbol RITA1 contributors: npt/shn - updated : 03-05-2018
HGNC name RBPJ interacting and tubulin associated 1
HGNC id 25925
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
Reproductivefemale systemuteruscervix predominantly
 female systemovary   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,nucleus
basic FUNCTION
  • acts as a negative modulator of the Notch signalling pathway, controlling the level of nuclear RBPJ/CBF-1 (
  • is a novel RBPJ-interacting protein that downregulates NOTCH1-mediated transcription
  • might suppress tumor growth and induce apoptosis in hepatocellular carcinoma (HCC)
  • export RBPJ out of the nucleus, thereby leading to the down-regulation of Notch target gene expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tubulin (
  • is a RBPJ (mammalian CSL ortholog)-interacting protein
  • endogenous RBPJ and RITA1 interact in cells, map the binding regions necessary for RBP-J/RITA complex formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS