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FLASH GENE
Symbol HDLBP contributors: mct/npt - updated : 24-09-2009
HGNC name high density lipoprotein binding protein
HGNC id 4857
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Connectivecartilage  highly
cell lineage proliferating cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • fourteen K homology (KH) motif
  • C-terminal domain binding to the histone methyltransferase SUV39H1 (Zhou 2008)
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to murine Hdlbp
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    intracellular,nuclear envelope,int
    text localize to heterochromatin (Wang 2005)
    basic FUNCTION
  • playing a role in cell sterol metabolism
  • may be functioning to protect cells from over-accumulation of cholesterol
  • RNA-binding protein previously implicated in heterochromatin formation and chromosome segregation (Zhou 2008)
  • plays a pivotal role in the endocrine regulation of both lipids and cholesterol (Chen 2003)
  • key regulator in proliferating cells (Felder 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in autism with deletion 2q37.3 (Feider 2009)
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS