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FLASH GENE
Symbol ADAT3 contributors: mct/npt - updated : 26-06-2008
HGNC name adenosine deaminase, tRNA-specific 3, TAD3 homolog (S. cerevisiae)
HGNC id 25151
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies homolog to S. Cerevisiae Tad3
Homologene
FAMILY
  • cytidine and deoxycytidylate deaminase family
  • ADAT3 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in inosine formation in tRNAs
  • with ADAT2 function as a heterodimer which catalyses inosine formation at the wobble position (position 34) in eukaryotic tRNAs
  • playing an essential role for cell viability, illustrating the biological importance of A-to-I editing at the wobble position of tRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS