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FLASH GENE
Symbol CACUL1 contributors: mct - updated : 05-04-2018
HGNC name CDK2-associated, cullin domain 1
HGNC id 23727
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear   highly
Lymphoid/Immunelymph node    
Reproductivefemale systemovary   
 female systemuterus   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CoRNR box
    • HOMOLOGY
    Homologene
    FAMILY
  • cullin family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • had an oncogene-like function related to cell cycle regulation
  • is an important factor for the protection of cells against APP toxicity and oxidative stress
  • is a novel type of RARA coregulator that interacts with RARA and inhibits its transcriptional activity
  • is a novel corepressor of RARA that cooperates with HDACs and is involved in the regulation of RA-induced cellular differentiation
  • impaired recruitment of ESR1 and KDM1A to the ESR1-responsive promoter, leading to greater H3K9me3 accumulation
  • CACUL1 function in human adipose-derived stem cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cooperates with histone deacetylases (HDACs) to suppress RARA, probably by associating with HDAC
  • associated with histone demethylase KDM1A and suppressed KDM1A-enhanced ESR1 activity
  • associated with KDM1A, functions as an ESR1 corepressor, implicating a potential antitumor target in ESR1-positive breast cancer
  • CACUL1/CAC1 is a positive regulator of the NFE2L2 pathway
  • directly associates with AR and suppresses AR transcriptional activity
  • CACUL1 is a novel regulator that negatively controls TP53 activity through the regulation of PML SUMOylation
  • CACUL1 tightly regulates PPARG signaling through the mutual opposition between SIRT1 and KDM1A, providing insight into its potential use for anti-obesity treatment
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    expression level of CACUL1 in the hippocampus of Alzheimer disease patients was significantly lower than that of normal controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    CACUL1 impairs KDM1A-mediated activation of AR, thereby implicating it as a potential antitumor target in prostate carcinoma
    ANIMAL & CELL MODELS