basic FUNCTION
| play roles in the proteolytic processing of prohormones, precursors of growth factors, and also in the pathogenicity of many viruses and bacteria |
|
is a functional protease that is capable of cleaving macromolecular substrates and can be inhibited by serine protease inhibitors of the Kunitz-type |
|
TMPRSS13, proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication |
|
membrane-anchored serine protease that serve as important regulators of multiple developmental and homoeostatic processes 3) |
|
contributes to stratum corneum formation and acquisition of the epidermal barrier |
|
supports stratum corneum formation and epidermal barrier formation by a mechanism that is independent of both epidermal profilaggrin processing and epidermal tight junction formation |
|
membrane-anchored serine protease important for epidermal development and acquisition of epidermal barrier function |
|
TMPRSS13 and, to a lesser degree, TMPRSS11E cleave and activate the spike proteins of the Middle East respiratory syndrome and severe acute respiratory syndrome coronaviruses for cell-cell and virus-cell fusion |
|
TMPRSS11E and TMPRSS13 activate the S proteins of the SARS- and MERS-CoVs and could contribute to syncytium formation in infected patients |
|
TMPRSS11E, TMPRSS13 activate influenza viruses and emerging coronaviruses in cell culture and, because of their expression in human lung tissue, might promote viral spread in the infected host |
|
is a glycosylated, active protease and its own proteolytic activity mediates zymogen cleavage |
|
exhibits impaired cell-surface expression in the absence of the cognate Kunitz-type serine protease inhibitors, hepatocyte growth factor activator inhibitor SPINT1 or SPINT2 |