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FLASH GENE
Symbol TMPRSS13 contributors: mct - updated : 02-04-2020
HGNC name transmembrane protease, serine 13
HGNC id 29808
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   lowly Homo sapiens
Lymphoid/Immunespleen   highly
 thymus   lowly Homo sapiens
Reproductivefemale systemovary  highly
 female systembreastmammary gland highly
 female systemplacenta  highly
 male systemprostate  lowly Homo sapiens
Respiratorylung     Homo sapiens
Skin/Tegumentskin     Homo sapiens
Urinarykidney   lowly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis   Homo sapiens
Muscularstriatumcardiac lowly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
Skin/Tegumentcornified cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • presence of a transmembrane domain located near the N-terminus
  • a unique and long cytoplasmic tail containing tandem repeat phosphorylation motifs of protein kinases
  • a transmembrane domain, and a trypsin-like serine protease domain at the extracellular C-terminal side
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • dominant form of TMPRSS13 on the cell surface is phosphorylated, whereas intracellular TMPRSS13 is predominantly non-phosphorylated
  • basic FUNCTION
  • play roles in the proteolytic processing of prohormones, precursors of growth factors, and also in the pathogenicity of many viruses and bacteria
  • is a functional protease that is capable of cleaving macromolecular substrates and can be inhibited by serine protease inhibitors of the Kunitz-type
  • TMPRSS13, proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication
  • membrane-anchored serine protease that serve as important regulators of multiple developmental and homoeostatic processes 3)
  • contributes to stratum corneum formation and acquisition of the epidermal barrier
  • supports stratum corneum formation and epidermal barrier formation by a mechanism that is independent of both epidermal profilaggrin processing and epidermal tight junction formation
  • membrane-anchored serine protease important for epidermal development and acquisition of epidermal barrier function
  • TMPRSS13 and, to a lesser degree, TMPRSS11E cleave and activate the spike proteins of the Middle East respiratory syndrome and severe acute respiratory syndrome coronaviruses for cell-cell and virus-cell fusion
  • TMPRSS11E and TMPRSS13 activate the S proteins of the SARS- and MERS-CoVs and could contribute to syncytium formation in infected patients
  • TMPRSS11E, TMPRSS13 activate influenza viruses and emerging coronaviruses in cell culture and, because of their expression in human lung tissue, might promote viral spread in the infected host
  • is a glycosylated, active protease and its own proteolytic activity mediates zymogen cleavage
  • exhibits impaired cell-surface expression in the absence of the cognate Kunitz-type serine protease inhibitors, hepatocyte growth factor activator inhibitor SPINT1 or SPINT2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TMPRSS13 functions as an HGF-converting protease, the activity of which may be regulated by SPINT1
  • cell & other
    REGULATION
    inhibited by strongly inhibited by aprotinin, benzamidine and Bowman-Birk trypsin inhibitor, but poorly inhibited by alpha 1-antitrypsin and leupeptin
    Other phosphorylation of TMPRSS13 is a novel post-translational modification
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    antiviral strategies aiming to prevent viral activation might thus need to encompass inhibitors targeting TMPRSS13 and TMPRSS11E
    ANIMAL & CELL MODELS
    Tmprss13-deficient mice displayed abnormal skin development, leading to a compromised barrier function, as measured by the transepidermal fluid loss rate of newborn mice