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FLASH GENE
Symbol RELL1 contributors: mct - updated : 24-10-2019
HGNC name RELT-like 1
HGNC id 27379
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Hearing/Equilibriumear   highly
Nervousnerve   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY RELT family
CATEGORY receptor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
basic FUNCTION
  • RELL1 and RELL2 interact with RELT and are phosphorylated by the OSR1 kinase (OXSR1)
  • overexpression of RELT or its homologues RELL1 and RELL2 in HEK 293 epithelial cells results in cell death with morphological characteristics consistent with the activation of an apoptotic pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RELL1 and RELL2 are two newly identified RELT homologues that bind to the TNF receptor family member RELT
  • cell & other
    REGULATION
    Other phosphorylated by the OSR1 kinase (OXSR1)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS