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FLASH GENE
Symbol SNF8 contributors: npt/ - updated : 29-10-2012
HGNC name SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
HGNC id 17028
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Lymphoid/Immunetonsils   highly
Reproductivefemale systemuterus  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain involved in the formation of a heterotetrameric ESCRTII complex
  • HOMOLOGY
    Homologene
    FAMILY
  • SNF8 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • detected on the limiting membrane of multivesicular endosomes
  • basic FUNCTION
  • required for efficient derepression of glucose-repressed genes
  • important role in ligand-induced EGFR and CXCR4 turnover, suggesting that termination of EGF signaling occurs prior to ESCRT-II engagement
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45
  • component of the ESCRT-II complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the N-terminal half of RILP
  • RILP interacts with SNF8 and VPS36 of ESCRT-II to mediate their membrane recruitment
  • MCM2 binds to SNF8 and MCM2 competes with ELL for binding to SNF8 thus potentially modulating the stability of Holo-ELL complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS