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FLASH GENE
Symbol FAAP100 contributors: mct/npt - updated : 12-09-2009
HGNC name chromosome 17 open reading frame 70
HGNC id 26171
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative coiled-coil domain that could mediate protein-protein interactions by either homodimerization or heterodimerization
  • HOMOLOGY
    Homologene
    FAMILY
  • Fanconi anemia core complex family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing an essential role for the stability of the core complex, and for the monoubiquitination of FANCD2
  • essential component of the FA-BRCA-associated DNA damage response network
  • having a function in transcriptional regulation, through two mechanisms: one involving direct binding of the FA complex to the HES1 promoter, and another in which the FA complex prevents HES1 from interacting with its co-repressor TLE, Transducin-like Enhancer of split (Tremblay 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of Fanconi complex, FA-BRCA DNA damage response network
  • FANC core subcomplex including FANCA, B, C, E, F, G, L, FAAP100 (Thompson 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with FANCB and FANCL to form a stable subcomplex
  • interacts with the transcriptional repressor Hairy Enhancer of Split 1 (HES1) suggesting that the core complex plays a role in transcription (Tremblay 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS