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FLASH GENE
Symbol VTCN1 contributors: - updated : 20-08-2007
HGNC name V-set domain containing T cell activation inhibitor 1
HGNC id 28873
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Reproductivefemale systemovary  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY B7 family
CATEGORY immunity/defense , antigen
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • functioning as a negative regulator of T cell responses
  • negatively regulates T cell immunity by the inhibition of T cell proliferation, cytokine production, and cell cycle progression
  • playing a potential role in the evasion of tumor immunity
  • potential activator that promotes tubular lesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein expressed on the surface of antigen-presenting cells and interact with ligands (CD28 on T lymphocytes)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in serous ovarian cancers and breast cancers with relatively little or no expression in normal tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target therapeutic antibody strategy aimed at VTCN1 could offer an exciting opportunity to inhibit the growth and progression of human ovarian and breast cancers
    ANIMAL & CELL MODELS