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FLASH GENE
Symbol SOCS7 contributors: mct - updated : 17-03-2020
HGNC name suppressor of cytokine signaling 7
HGNC id 29846
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
 male systemprostate  highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal SH2 domain, was responsible for the binding to vinexin (likely one of the SH3 domains of vinexin interacts with a poly-proline region of SOCS7)
  • a central region containing several proline-rich regions
  • HOMOLOGY
    Homologene
    FAMILY
  • SOCS protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • potent regulator of glucose homeostasis and insulin signaling
  • inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation
  • shuttling protein that transports cytoplasmic proteins into the nucleus and contributes to cell cycle arrest
  • SOCS7 is involved in the regulation of thymic stromal lymphopoietin (TSLP) signaling in mast cells
  • SOCS7 controls Muller glia cell lamination, but it is not responsible for cone photoreceptor positioning
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • vinexin (SORBS3) as a partner interacting with SOCS7 (interacts with vinexin and the actin cytoskeleton)
  • connection between septins, SOCS7, NCK1 signaling, and the DNA damage response
  • SOCS7 interact with PLCG1, one of the insulin-like growth factor-1 (IGF1) receptor downstream molecules
  • SOCS7, a Cullin 5-RING E3 ubiquitin ligase (CRL5 substrate adaptor protein, is also required for neocortical layering
  • by terminating RELN signaling, SOCS6 and SOCS7 may allow new cycles of RELN signaling to occur and these may be essential for cortical neuron migration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Alzheimer disease brains
    tumoral     --over  
    significantly associated with earlier tumour stage and better clinical outcome in human breast cancer
    Susceptibility to obesity, disturbances in lipid metabolism and insulin resistance
    Variant & Polymorphism other associations between SOCS7 common variants and related haplotypes and obesity, Insulin resistance and lipid metabolism disorders
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Socs7 deficient mice develop islet hyperplasia in the setting of increased insulin sensitivity and normal glucose tolerance
  • lack of Socs7 is associated with severe skin disease in mice