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FLASH GENE
Symbol AGMO contributors: mct - updated : 30-05-2018
HGNC name alkylglycerol monooxygenase
HGNC id 33784
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text in the superior temporal gyrus of fetal brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • fatty acid hydroxylase motif, motif found in enzymes which contain a di-iron center and which carry out hydroxylations of lipids at aliphatic carbon atoms like alkylglycerol monooxygenase
  • HOMOLOGY
    Homologene
    FAMILY
  • tetrahydrobiopterin-dependent enzymes family
  • TMEM195 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having a catalytic activity
  • regulatory enzyme in lipogenesis, catalyzing the rate-limiting step in the overall de novo synthesis of mono-unsaturated FA, mainly oleate and palmitoleate from stearoyl- and palmitoyl-CoA, respectively
  • cleave the O-alkyl bond of ether lipids which are essential components of brain membranes, protect the eye from cataract, interfere or mediate signaling processes, and are required for spermatogenesis
  • only enzyme known to degrade the ether bond of lipids without known restrictions to their subclass, and may contribute to regulation of the concentration of these lipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to autism spectrum disorder
  • to intracranial aneurysms
  • to decreased glucose-stimulated insulin response
  • Variant & Polymorphism SNP , other
  • de novo copy number variant in autism spectrum disorder
  • rs4628172 and rs7781293 increasing the risk of intracranial aneurysms
  • variants at the DGKB/AGMO, ADRA2A, GLIS3 and C2CD4B loci were associated with decreased glucose-stimulated insulin response
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS