basic FUNCTION
| acting by recruiting TOP3A to double Holliday junctions |
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promoting the BLM-dependent dissolution of homologous recombination intermediates |
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acting as an essential component of the BLM-associated cellular machinery that maintains genome integrity |
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required for the stability of the BLM/RMI1/TOP3A complex and for the suppression of elevated sister chromatids exchange (SCE) |
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dual-role of RMI1 in embryonic development and tumor suppression |
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RMI1 functions downstream of BLM in promoting replication elongation |
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direct roles of RMI1 in DNA replication and the replication stress response, which could explain the molecular basis for its involvement in suppressing sister chromatid exchange and tumorigenesis |
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functions with BLM and TOP3A to suppress illegitimate recombination |
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RMI1 and TOP3A participate in the DNA replication stress response |
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RMI1 protein level does not change through G1, S and G2 phases, but significantly increases in M phase |