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FLASH GENE
Symbol DENND6A contributors: mct - updated : 25-01-2017
HGNC name DENN domain containing 6A
HGNC id 26635
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
 thyroid   highly
Hearing/Equilibriumearinnercochlea  
Lymphoid/Immunethymus    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine A630054L15Rik
Homologene
FAMILY
  • FAM116 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • DENND6A and AVL9 are required for cell migration
  • DENND6A, DENND6B and RAB14 therefore define an endocytic recycling pathway needed for ADAM protease trafficking and regulation of cell-cell junctions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS