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FLASH GENE
Symbol BTD contributors: - updated : 12-01-2007
HGNC name biotinidase
HGNC id 1122
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   predominantly
Endocrineadrenal gland   predominantly
Nervousnervecranial nerve   
Urinarykidney   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six potential N-glycosylation sites
  • at least nine isoforms differing from the degree of sialylation
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Vnn1
    Homologene
    FAMILY
  • CN hydrolase family
  • BTD/VNN subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular serum
    basic FUNCTION
  • catalyzing the recycling of biotin by cleaving biocytin (biotin epsilon lysine)
  • also biotinyl transferase activity
  • biotine carboxylase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text development of central nervous system and epidermal differentiation
    PATHWAY
    metabolism vitamin
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    biotin (prosthetic group of the four carboxylases)
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BTD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS