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FLASH GENE
Symbol NIBAN2 contributors: mct - updated : 13-04-2021
HGNC name niban apoptosis regulator 2
HGNC id 25282
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Reproductivefemale systemplacenta   
 female systemuteruscervix  
 male systemprostate   
Respiratorylung    
Skin/Tegumentskin     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PH or pleckstrin homology domain found near the N-terminus of the polypeptide (AAs 69192)
  • near the C terminus is a region rich in proline phosphorylated at six serine residues (AAs 628730))
  • HOMOLOGY
    interspecies ortholog to murine 9130404D14Rik
    Homologene
    FAMILY
  • Niban family, FAM129 protein family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • can be localized in the cytosol or associated with the cell junctions
  • localized in the plasma cell membrane during mitosis
  • basic FUNCTION
  • plays a critical role in cancer cell invasion
  • implicated in cell invasion in human melanoma cells in a process controlled by the Erk1/2 signaling cascade
  • one crucial facet of the mechanism by which FAM129B promotes cancer cell invasion is likely to be the suppression of apoptosis
  • expression of NIBAN2 in epidermal keratinocytes accompanied by alteration of wound healing-related gene expression is likely necessary for regulation of cell motility and thereby, contributes to the appropriate wound healing process
  • role for FAM129B in linking WNT/CTNNB1 signaling to apoptosis in melanoma
  • is involved in key signaling pathways regulating cell survival, proliferation and apoptosis and found upregulated in many types of cancer promoting invasion
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • normal component of the adherens junction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of the MAP kinase (Erk1/2) signaling cascade in human melanoma cells
  • NIBAN2 phosphorylation increased the interaction between NIBAN2 and RAS, resulting in reduced binding of RASA1 to RAS
  • NIBAN2 induces NFE2L2 by competing for Kelch-like ECH-associated protein 1 (KEAP1) binding (the negative regulator of NFE2L2) via an ETGE motif
  • phosphorylation of NIBAN2 plays a significant role in driving the metastatic potential of BRAF V600E melanoma via upregulation of the NFE2L2 signaling pathway
  • cell & other
    REGULATION
    Other rapid cleavage of FAM129B and cadherin that occurred during apoptosis may be a mechanism that ensures that the antiapoptotic function
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    is a potential therapeutic target
    ANIMAL & CELL MODELS