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FLASH GENE
Symbol LETMD1 contributors: mct - updated : 19-03-2007
HGNC name LETM1 domain containing 1
HGNC id 24241
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
Endocrineadrenal gland   moderately
 parathyroid   highly
 thyroid   moderately
Respiratoryrespiratory tracttrachea  moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Letmd1 (80.00 pc)
Homologene
FAMILY
CATEGORY regulatory , protooncogene
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • may be a negative regulator of the p53 tumor suppressor
  • playing a role in developpement of human breast cancer
  • acting as a negative regulator of TP53 and contributes to tumorigenesis of various organs including the colon
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with REEP5
    cell & other
    REGULATION
    induced by the PI3K/Akt signaling pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS