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FLASH GENE
Symbol LARP4 contributors: mct - updated : 07-03-2022
HGNC name La ribonucleoprotein domain family, member 4
HGNC id 24320
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
Nervousnerve    
Reproductivefemale systembreastmammary gland  
Urinarybladder    
 kidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one HTH La-type RNA-binding domain
  • a PAM2 motifs with variable affinities for the MLLE domain of PABPC1
  • HOMOLOGY
    Homologene
    FAMILY
  • LARP family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • is a La-related RNA-binding protein implicated in regulating mRNA translation
  • regulates cancer cell migration and invasion
  • LARP4 is a posttranscriptional regulator of ribosomal protein production in mammalian cells, suggesting that this activity can be controlled by tRNA levels
  • likely LARP4 opposes deadenylation by stabilizing PABPC1 on mRNA poly(A) tails
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • LARP1 and LARP4 bind and protect mRNA 3' poly(A) tails from deadenylases through close contact with PABPC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS