SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,nucleus
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| nuclear LPCAT1 colocalizes with and binds to histone H4, where it catalyzes histone H4 palmitoylation |
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LPCAT1 and LPCAT2 can localize to the lipid droplets (LDs)surface |
basic FUNCTION
| might synthesize phosphatidylcholine in pulmonary surfactant and play a pivotal role in respiratory physiology |
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plays a critical role in regulating surfactant phospholipid biosynthesis |
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may be catalyzing the conversion of lysophosphatidylcholine to dipalmitoylphosphatidylcholine in alveolar type II cells |
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plays a role in the noninflammatory response to oxidization and inflammation |
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converts lysophosphatidylcholine into phosphatidylcholine |
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phosphatidylcholine reacylating enzyme in red blood cells |
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may contribute to total choline metabolite accumulation via phosphatidylcholine remodeling, thereby altering the colorectal carcinoma lipid profile, a characteristic of malignancy |
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possesses lysophosphatidylcholine acyltransferase (LPCAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities |
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may have evolved along with the lung to facilitate respiration and is the biosynthetic enzyme of pulmonary surfactant phospholipids |
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required for pulmonary surfactant homeostasis, and to achieve the levels of saturated phosphatidylcholine essential for the transition to air breathing |
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importance of LPCAT1 in diverse cellular processes, with an as yet undefined new role in photoreceptor biology |
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LPCAT1 and LPCAT2 have, in addition to their known function in specialized cells, a ubiquitous role in lipid droplets (LDs)-associated lipid metabolism |
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is a critical cytosolic enzyme needed for lung surfactant synthesis that catalyzes an acyltransferase reaction by adding a palmitate to the sn-2 position of lysophospholipids |
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modulation of the lipid droplets (LDs) pool by LPCAT1 influences the release of lipoprotein from liver cells |
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is required in the biosynthesis of pulmonary surfactant |
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is necessary for photoreceptors to generate an important lipid component of their membranes |
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is a key enzyme in the synthesis of platelet-activating factor (PAF), as well as DPPC, a highly surface-active glycerophospholipid component of surfactant |