basic FUNCTION
| may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma |
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activating STAT1, STAT3 and STAT5 |
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might contribute to the development of AD-induced skin inflammation and pruritus |
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cytokine involved in pruritic skin diseases including atopic dermatitis (AD) and chronic spontaneous urticaria |
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functional role of I31 in in human primary keratinocytes (HPKs) |
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is a key mediator of itching in atopic dermatitis (AD) and is preferentially produced by activated CD4(+) T cells and Th2 cells |
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OSM and interleukin-31 (IL31) are two cytokines belonging to the IL6 family which share a common signaling receptor subunit, OSMR |