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FLASH GENE
Symbol HSPA14 contributors: mct - updated : 26-09-2012
HGNC name heat shock 70kDa protein 14
HGNC id 29526
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
Endocrineparathyroid   highly
Gustatory (taste)tongue    
Lymphoid/Immunelymph node   highly
 tonsils   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Hspa14 (91.0pc)
homolog to rattus Hspa14 (90.2pc)
Homologene
FAMILY heat shock protein 70 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle
intracellular,cytoplasm,cytosolic,ribosome
basic FUNCTION
  • involved in dendritic cells maturation and activation
  • induces phenotypic and functional maturation of dendritic cells in a TLR4-dependent manner
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    pathway (NBN-HSF4-HSPA4/HSPA14 axis) to induce migration, invasion, and transformation, suggesting the activation of multiple signaling events induced by NBN overexpression
    a component forms a stable complex with DNAJC2 (chaperones DNAJC2 and HSPA14 form the ribosome-associated complex)
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • interacting with NBN (NBN overexpression induced the expression of HSF4, which correlated with the expression of HSPA4 and HSPA14
  • binds directly to TLR4 on the surface of dendritic cells, activates MAPK and NFKB pathways
  • key receptor mediating the interaction of HSPA14 with dendritic cells and subsequently enhancing the induction of Th1 immune response by HSPA14/antigen fusion protein
  • key role for TLR4 in mediating HSPA14 interaction with dendritic cells
  • cell & other
    REGULATION
    induced by heat stress, TNF-alplha and phorbol esters
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS