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FLASH GENE
Symbol SYNPO2L contributors: npt - updated : 26-05-2006
HGNC name synaptopodin 2-like
HGNC id 23532
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • rich in proline and containing multiple PXXP motifs that could function as potential peptide ligand motifs for SH3 domain containing proteins
  • one PPXY motif
  • HOMOLOGY
    intraspecies homolog to synaptopodin
    Homologene
    FAMILY
  • synaptopodin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text localized in dense bodies and in Z-lines of striated muscle
    basic FUNCTION
  • increases the rate of actin polymerization by accelerating the nucleation phase and exhibits a high potency to bundle actin filaments
  • playing a role in organizing cellular actin
  • may be stabilizing the formation of actin nuclei
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the cytoskeleton
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with calmodulin in a Ca2+-dependent manner
  • actin binding protein
  • multiple binding partners including myosin, calmodulin and alpha-actinin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS