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FLASH GENE
Symbol GPKOW contributors: mct - updated : 16-09-2019
HGNC name G patch domain and KOW motifs
HGNC id 30677
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
Reproductivefemale systemuteruscervix  
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a G-patch domain and two KOW domains
  • two KOW motifs of human GPKOW span the amino acids 240 through 267 and 415 through 442
  • three nucleic acid binding domains
  • secondary structure
  • G-patch domain of GPKOW forms two alpha-helixes that are capable of binding single-stranded RNA and DNA as well as proteins
  • HOMOLOGY
    interspecies homolog to Saccharomyces Spp2
    homolog to murine Gpkow (77.4pc)
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • is found in the human spliceosome
  • evenly distributed in the nucleus, but excluded from the nucleoli
  • basic FUNCTION
  • is a RNA-binding protein that binds RNA in a PRKAA regulated fashion
  • GPKOW can functionally impact DHX16 but that interaction between the proteins is not required for this activity
  • is essential for fetal development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA RNA- binding protein
    small molecule other,
    protein
  • during step 1 of splicing, PRPF8 interactions with SF3b proteins are replaced by SLU7, positioning this second step factor close to the active site, and that the DEAH-box helicases DHX16 and DHX38 cooperate through ordered interactions with GPKOW (PMIDl:
  • GPKOW interacted directly with the DHX16/hPRP2 and with RNA
  • acts as an essential cofactor for the two DEAH-box helicases, DHX16 and DHX38, which sequentially catalyze the key transesterification reactions
  • cell & other
    REGULATION
    Other GPKOW ability to bind RNA is regulated by PRKACA-dependent phosphorylation at two sites
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH26
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS