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FLASH GENE
Symbol H2BFM contributors: KTN/npt - updated : 20-01-2009
HGNC name H2B histone family, member M
HGNC id 27867
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
mono polymer heteromer , octamer
HOMOLOGY
Homologene
FAMILY
  • histone H2B family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • involved in wrapping and compacting DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template
  • playing a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • core component of nucleosome composed of a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS