SUBCELLULAR LOCALIZATION
| extracellular
|
| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria,outer
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,cytosolic,microsome
|
| intracellular,nucleus,nucleoplasm
|
| intracellular,nucleus,nucleolus
|
| intracellular,nuclear envelope
|
text
| highly active in the spleen |
|
is not present in the mitochondria despite the fact that the organelle is the site of heme synthesis and contains multiple heme proteins |
basic FUNCTION
| rate limiting enzyme in the degradation of heme to biliverdin, inducible form, potent anti-inflammatory proteins whenever oxidation injury takes place |
|
playing a critical role in FOXP3-mediated immune suppression |
|
catabolizes heme into products exhibiting potent anti-inflammatory properties |
|
supports neoplastic mast cell survival |
|
has the potential to incorporate into phospholipid membranes, which can be reconstituted at known concentrations, in combination with other endoplasmic reticulum resident enzymes |
|
novel role of BMP6/HMOX1 cascade to relieve breast cancer metastasis by regulating the secretion of growth factors in tumor microenvironment |
|
tumorigenic role of HMOX1 and the importance of RNF139-mediated HMOX1 degradation in the control of cancer growth |
|
exerts a protective effect in retinal endothelial cells exposed to hyperglycemic and oxidative/nitrosative stress conditions |
|
has a critical role in the modulation of peritoneal fibrosis, and, more important, the suppression of EMT |
|
emerges as one important modulator of innate immune responses in pregnancy |
|
plays an important role in the vasculature and in the angiogenesis of tumors, wounds and other environments |
|
might have an angiogenic effect in choroidal neovascularization (CNV) through modulation of VEGFA expression |
|
catalyzes the first and rate-limiting enzymatic step of heme degradation and produces carbon monoxide, free iron, and biliverdin |
|
catalyzes the oxidative degradation of heme |
|
progesterone and HMOX1 promote fetal growth by CD8+ T cell modulation |
|
is a mediator of ATF4-dependent anoikis resistance and tumor metastasis |
|
plays an important role in the development of chronic obstructive pulmonary disease (COPD) |
|
is a modulator of intestinal inflammation development and progression in inflammatory bowel diseases |
|
HMOX1 promotes ferroptosis induced by erastin in lens epithelial cell through modulates Fe2+ production |
|
HMOX1 is involved in the pathogenesis of pre-eclampsia (PE) by regulating the proliferation, apoptosis, and angiogenesis modulation potential of Mesenchymal stem cells (MSCs) via VEGFA |