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FLASH GENE
Symbol MXD1 contributors: mct/npt/pgu - updated : 09-09-2009
HGNC name MAX dimerization protein 1
HGNC id 6761
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestine   highly
 mouthtongue  highly
 pharynx   highly
Endocrineparathyroid   highly
Lymphoid/Immunethymus   predominantly
Reproductivemale systemprostate   
Respiratorylung   moderately
 respiratory tractlarynx   
 respiratory tracttrachea  moderately
Visualeye   moderately
cell lineage
cell lines
fluid/secretion highly in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a basic helix-loop-helix (bHLH) motif
  • a nuclear localization signal
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Mxd1 (89.6 pc)
    homolog to murine Mxd1 (89 pc)
    Homologene
    FAMILY
  • subfamily of MAX-interacting proteins
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a transcriptional repressor
  • antagonizing MYC transcriptional activity through interaction with the N-COR/SIN3/HDAC corepressor complex (by the recruitment of opposing chromatin remodeling activities compared to Myc)
  • inhibiting apoptosis via downregulation of PTEN expression
  • interacts with NEK2 at the kinetochore and possibly functions as a novel integrator of spindle checkpoint signaling
  • key role for the MYC-MAX-MXD1 network in the development and progression of neural crest tumors
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text multicellular organismal development
    PATHWAY
    metabolism
    signaling
    a component
  • forming a sequence-specific DNA-binding complex with MAX
  • part of the MYC-MAX-MXD1 network
  • INTERACTION
    DNA binding the enhancer box (E box) hexanucleotide (5-prime-CACGTG-3-prime) when heterodimerized with MAX
    RNA
    small molecule
    protein
  • Max heterodimeric partner
  • TERT telomerase reverse transcriptase
  • cell & other
    REGULATION
    induced by CSF3
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS